The inhibition of intestinal glucose absorption by oat-derived avenanthramides

Zhouyao, H., Malunga, L. N., Chu, Y., Eck, P., . . . Thandapilly, S. J. (2022). The inhibition of intestinal glucose absorption by oat-derived avenanthramides. Journal of Food Biochemistry, 46(10), e14324. doi:10.1111/jfbc.14324



Avenanthramides are phenolic compounds unique to oats and may contribute to health-promoting properties associated with oat consumption. This study used Xenopus laevis oocytes expressing the glucose transporters, glucose transporter 2 (GLUT2) or sodium–glucose transport protein 1 (SGLT1) and human Caco-2 cells models to investigate the effect of oat avenanthramides on human intestinal glucose transporters. The presence of avenanthramide reduced the glucose uptake in a dose-dependent manner in Caco-2 cells. Glucose uptake in oocytes expressing either GLUT2 or SGLT1 was nullified by oat avenanthramide. There was no significant difference between the inhibition potencies of avenanthramides C and B. Thus, our results suggest that avenanthramides may contribute to the antidiabetic properties of oats.